Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: “Within each stratum, 4 collines were selected by using random numbers with a fixed random number seed in Stata version 11 [StataCorp (8)], for a total of 60 collines. At a public lottery event organized in Ruyigi, at which representatives from both provinces were present, the 4 collines in each stratum were each randomised to 1 of the 4 study arms”
		Comment: Adequately done
Allocation concealment (selection bias)	Unclear risk	Comment: Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)	Unclear risk	Comment: Insufficient information to permit judgement
Blinding of outcome assessment (detection bias)	Unclear risk	Comment: Insufficient information to permit judgement
Incomplete outcome data (attrition bias)	Unclear risk	Comment: Insufficient information to permit judgement
Selective reporting (reporting bias)	High risk	Comment: Outcomes mentioned in methodology section and protocol are not provided in supplementary documents (NCT01072279)
Other bias	Low risk	Comment: No other potential sources of bias reported
Was the allocation sequence adequately generated?	Unclear risk
Was the allocation adequately concealed?	Unclear risk
Were baseline outcome measurements similar?	Unclear risk
Were baseline characteristics similar?	Unclear risk
Were incomplete outcome data adequately addressed?	Unclear risk
Was knowledge of the allocated intervention adequately prevented during the study?	Unclear risk
Was the study adequately protected against contamination?	Unclear risk
Was the study free from selective outcome reporting?	Unclear risk
Was the study free from other risk of bias?	Unclear risk