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. 2021 May 5;17(2):e1156. doi: 10.1002/cl2.1156
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk

Quote: “The randomisation was done at the class section level for 60 class sections.”

Comment: method of sequence generation was not described

Allocation concealment (selection bias) Low risk Comment: since randomisation was performed at class section level it is unlikely a selection bias is present at individual level
Similar baseline characteristics Unclear risk
Similar baseline outcome measurement Unclear risk
Blinding of participants and personnel (performance bias) High risk Comment: all groups received the supplement and no placebo was used
Blinding of outcome assessment (detection bias) Low risk Comment: outcomes were objective therefore the blinding of outcome assessors would not impact the results
Incomplete outcome data (attrition bias) Low risk

Quote: “Seven girls in the daily administered group during the second week of intervention complained of gastric side effects and requested not to continue in the study and were excluded”

Comment: incomplete outcome data were matched across groups.

Prevention of knowledge of allocated intervention Unclear risk
Protection against contamination Unclear risk
Selective reporting (reporting bias) Unclear risk

Quote: “Girls with haemoglobin <70 g/L (0.3%)were eliminated from the analysis.” “Plasma ferritin and C‐reactive proteins (CRP) were estimated in every tenth girl of the study groups”

Comment: it is unclear how each girl was selected for these analyses. Data not available for the second measurement. However no protocol could be found and therefore there is insufficient evidence to make a judgement.

Other bias Low risk Comment: the study appears to be free of other bias