Bias | Authors' judgement | Support for judgement |
---|---|---|
Random sequence generation (selection bias) | Unclear risk |
Quote: “The randomisation was done at the class section level for 60 class sections.” Comment: method of sequence generation was not described |
Allocation concealment (selection bias) | Low risk | Comment: since randomisation was performed at class section level it is unlikely a selection bias is present at individual level |
Similar baseline characteristics | Unclear risk | |
Similar baseline outcome measurement | Unclear risk | |
Blinding of participants and personnel (performance bias) | High risk | Comment: all groups received the supplement and no placebo was used |
Blinding of outcome assessment (detection bias) | Low risk | Comment: outcomes were objective therefore the blinding of outcome assessors would not impact the results |
Incomplete outcome data (attrition bias) | Low risk |
Quote: “Seven girls in the daily administered group during the second week of intervention complained of gastric side effects and requested not to continue in the study and were excluded” Comment: incomplete outcome data were matched across groups. |
Prevention of knowledge of allocated intervention | Unclear risk | |
Protection against contamination | Unclear risk | |
Selective reporting (reporting bias) | Unclear risk |
Quote: “Girls with haemoglobin <70 g/L (0.3%)were eliminated from the analysis.” “Plasma ferritin and C‐reactive proteins (CRP) were estimated in every tenth girl of the study groups” Comment: it is unclear how each girl was selected for these analyses. Data not available for the second measurement. However no protocol could be found and therefore there is insufficient evidence to make a judgement. |
Other bias | Low risk | Comment: the study appears to be free of other bias |