Table 2.
Associations with onset age of migraine
| Risk allele frequency | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age of Onset | SNP | Position (GRCh38.p12) | MAF | TWB | Gene | Type | Variant Change | ≤ 12 | > 12 | P-value | OR |
| ≤ 12 vs. >12 | rs146094041 | chr1:217,092,941 | 0.01 | 0.02 | ESRRG | intronic/Del | CAA > - | 6.78 % | 0.38 % | 3.40 × 10− 9* | 0.053 [0.014,0.20] |
Patients with migraine were grouped based on the age of onset and were compared using PLINK
ESRRG estrogen-related receptor gamma, MAF minor allele frequency of East Asian group in dbSNP, TWB minor allele frequency in the Taiwan Biobank
Significant variants with P < 5× 10− 8 are listed with the allele frequency and odds ratio (OR) with 95 % confident interval for the phenotype association study on the onset of migraine before or after 12 years of age
* is the criteria whose P-value was <