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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: Arch Toxicol. 2019 Sep 25;93(11):3099–3109. doi: 10.1007/s00204-019-02574-8

Figure 3.

Figure 3.

(a) PCA plot of the top 50 most variable miRNAs across all samples and (b) volcano plot of miRNA expression changes after exposure to iAsIII, Cd, or Mn. Vertical lines represent a fold change of +/− 1.5, and the horizontal line is an adjusted p-value of 0.05; N=3 per treatment group (c) RT-qPCR validation of sequencing results for two robustly expressed miRNAs altered by metal exposure, miR-146a and miR-708. Data are represented as mean of technical replicates (N=12 for each exposure) + SE for 3 or more biological replicates. *p <0.05; **p < 0.01; ***p < 0.001 treatment versus control relative expression.