Figure 4.
GSIS (a) and miR-146a (b) expression (as determined by RT-qPCR) after 24-hour exposure to 0.5 or 1 μM iAs (miR-146a, 0 μM iAs N=27, 0.5 μM iAs N=15, 1 μM iAs N=22). Also, GSIS (c) and miR-146a (d) expression after 24-hour exposure to 1 μM iAs or 0.5 μM MAs (miR-146a, 0 μM iAs N=12, 0.5 μM iAs N=9, 1 μM iAs N=12). Data are represented as mean of technical replicates + SE for 3 or more biological replicates. *p < 0.05; **p < 0.01; ***p < 0.001 treatment versus control high glucose stimulation or treatment versus control relative expression.
