| Signalling questions | Response options | |
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| 3.1 Were data for this outcome available for all, or nearly all, participants randomized? |
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| 3.2 If N/PN/NI to 3.1: Is there evidence that result was not biased by missing outcome data? |
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| 3.3 If N/PN to 3.2: Could missingness in the outcome depend on its true value? |
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| 3.4 If Y/PY/NI to 3.3: Do the proportions of missing outcome data differ between intervention groups? |
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| 3.5 If Y/PY/NI to 3.3: Is it likely that missingness in the outcome depended on its true value? |
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| Risk‐of‐bias judgement | Low/High/Some concerns | |
| Optional: What is the predicted direction of bias due to missing outcome data? | Favours experimental / Favours comparator/Towards null /Away from null/Unpredictable |