Pearson correlation analysis of UMAP, t-SNE, PCA, and tICA calculated based on the 2D reduced representations. A) Pearson correlations values between projected and high-dimensional trajectories. B) Scatterplots where the X-axis represent the distances in the high dimensional space, while the Y-axis represent the distances in the low dimensional space. The coloring represents the agreement between the original and projected distances. Red and blue represent agreement and disagreement, respectively.