TABLE 1.

Top 10 host proteins, pathways and GO processes associated with SARS-CoV-2 infection.

Rank	Protein	Protein relationships	Pathway	Pathway relationships	Process	Process relationships
1	ACE2	6,413	Immune system	12,237	Positive regulation of transcription by RNA polymerase II	5,287
2	CDSN	3,873	Cytokine signaling in immune system	9,004	Viral entry into host cell	4,513
3	TMPRSS2	1,279	Metabolism of proteins	8,201	Signal transduction	3,815
4	DPP4	1,132	Signal transduction	7,345	Positive regulation of gene expression	3,490
5	ANPEP	1,032	Disease	4,109	Positive regulation of cell population proliferation	3,212
6	CD8A	816	Gene expression (transcription)	3,095	Negative regulation of transcription by RNA polymerase II	3,150
7	IFNG	774	RNA polymerase II transcription	2,960	Positive regulation of transcription, DNA-templated	3,141
8	CLEC4M	747	Post-translational protein modification	2,945	Negative regulation of cell population proliferation	2,895
9	CTSL	742	Generic transcription pathway	2,940	Positive regulation of NF-kappaB transcription factor activity	2,390
10	IL6	726	Signaling by receptor tyrosine kinases	2,802	MAPK cascade	2,361