TABLE 2.

Top 20 enriched biological pathways (Reactome) in the final network.

Rank	Name	p value	Matched	Gene set
1	Immune system	1.32E-102	343	2,129
2	Cytokine signaling in immune system	6.36E-82	222	875
3	Signaling by interleukins	2.02E-66	155	458
4	Clathrin-mediated endocytosis	3.47E-40	75	145
5	Innate immune system	1.65E-27	150	1,044
6	Interleukin-10 signaling	3.91E-25	37	45
7	Cargo recognition for clathrin-mediated endocytosis	8.56E-25	49	105
8	Toll-like receptor cascades	3.97E-24	56	153
9	Vesicle-mediated transport	3.10E-23	111	669
10	Membrane trafficking	1.83E-21	104	630
11	Interleukin-4 and Interleukin-13 signaling	1.58E-20	44	108
12	Toll like receptor 4 (TLR4) cascade	8.76E-20	46	127
13	Interleukin-2 family signaling	3.31E-17	28	44
14	Interferon alpha/beta signaling	4.17E-17	33	70
15	Chemokine receptors bind chemokines	1.19E-16	30	57
16	Signal transduction	4.79E-16	217	2,786
17	Interferon signaling	2.30E-14	47	197
18	Diseases associated with the TLR signaling cascade	3.40E-14	20	24
19	Diseases of immune system	3.40E-14	20	24
20	Adaptive immune system	9.90E-14	96	745