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. 2021 Jul 28;12:709856. doi: 10.3389/fphar.2021.709856

TABLE 3.

Top 20 enriched biological processes (Gene Ontology) in the final network.

Rank Name p value Matched Gene set
1 Cytokine-mediated signaling pathway 1.04E-71 116 279
2 Inflammatory response 1.49E-46 100 381
3 Membrane organisation 4.63E-44 66 133
4 Immune response 9.65E-42 85 297
5 Viral entry into host cell 1.83E-36 51 89
6 Innate immune response 2.40E-36 94 457
7 Positive regulation of interleukin-6 production 1.71E-30 45 89
8 Cellular response to lipopolysaccharide 6.86E-29 53 157
9 Defense response to virus 1.04E-28 58 200
10 Positive regulation of NF-kappaB transcription factor activity 7.07E-27 51 160
11 Response to virus 1.67E-25 42 104
12 Positive regulation of interleukin-8 production 1.40E-22 31 54
13 Endocytosis 3.11E-22 48 184
14 Positive regulation of I-kappaB kinase/NF-kappaB signaling 3.78E-22 48 185
15 Signal transduction 2.14E-21 108 1,006
16 Positive regulation of tyrosine phosphorylation of STAT protein 2.92E-21 32 68
17 Type I interferon signaling pathway 8.02E-20 30 65
18 I-kappaB kinase/NF-kappaB signaling 1.12E-19 30 66
19 Chemokine-mediated signaling pathway 1.57E-19 30 67
20 Positive regulation of tumor necrosis factor production 1.78E-19 27 49