Table 3.
Histomorphology (MEST & Haas's classification, Immunofluorescences and Electron microscopic findings in primary IgA nephropathy, IgA vasculitis nephritis (HSP), IgA dominant nephritis and Secondary IgAN
| S.No. | Types IgAN | Investigations | |||||||||||
| Histomorphology(%) | Immunofluorescence (%) | Electron microscopy(%) | |||||||||||
| MEST-C classification |
Haas's classification |
Skin biopsy |
IgG | IgA | IgM | C3 | F.H. | MeD | SubEnD | SubEpD | Both | ||
| Renal biopsy | |||||||||||||
| 1. | Primay IgAN | Me-59 En-10.4 SG-20.9 C1–3.6 C2–5.3 T0-2.8 T1-11.5 T2-9.6 N-1.03 |
Cl I -11.1 Cl II-10.6 Cl III-13 Cl IV-7.5 Cl V-16.2 |
- | 1.6 | 100 | 4.5 | 4.6 | 0.2 | 26.4 | 0.58 | 0 | 17.3 |
| 2. | IgAVN | Me-9.7 En-6.7 SG-0.7 C1-2.2 T0-2.2 |
- | LC-33.8 | 0 | 100 | 0 | 22.5 | 0 | - | - | - | - |
| 3. | IgADN | Me-29.4 En-47.0 C2-58.8 |
- | - | 12.2 | 100 | 1 | 89.7 | 0 | 0 | 5.8 | 11.7 | 5.8 |
| 4. | Secondary IgAN |
Me-95.2 En-23.8 SG-33.3 C1-19 T0-14.2 |
- | - | 16.6 | 100 | 5.9 | 9.5 | 0 | 9.5 | 0 | 4.7 | 0 |
Me-Mesangial proliferation, En-Endocapillary proliferation, SG-Segmental Glomerulosclerosis, C1- <25% Cellular/fibrocellular crescent, C2- >25%Cellular/Fibrocellular crescent, T0- ≤25%TA/IF T1- 26% to 50% TA/IF, T2->50%TA/IF, N-Normal, Cl- Class, MeD-mesangial deposition, SubEnD-subenothelial deposition, SubepD-subepithelial deposition, Both-MeD+EnD, ,HistoM-histomorphology, LC- leukocytoclastic vasculitis ,F.H.-Full House