Table 3.
Anti-inflammatory effect of dichloromethane leaf extract of E. globulus (Labill) on carrageenan-induced inflammation in Swiss albino mice
| Group | Treatment | Percentage change in paw circumference (mm) | ||||
|
| ||||||
| 0h | 1h | 2h | 3h | 4h | ||
|
Normal
control |
DMSO (vehicle) | 100.00±0.00 | 100.00±0.00bc (0.00) |
100.00±0.00b (0.00) |
100.00±0.00 b (0.00) |
100.00±0.00 b (0.00) |
|
Negative
control |
Carrageenan + DMSO only | 100.00±0.00 | 103.06±0.44a (-3.06) |
106.65±0.42a (-6.65) |
108.18±0.36a (-8.18) |
109.11±0.39a (-9.11) |
|
Positive
control |
Carrageenan + Diclofenac (15mg/kg bw) |
100.00±0.00 | 98.23±0.15d (1.77) |
93.57±0.23f (6.43) |
92.11±0.32ef (7.89) |
90.03±0.17ef (9.97) |
|
DCM leaf
extract |
Carrageenan+ 25mg/kg bw | 100.00±0.00 | 100.81±0.50b (-0.81) |
100.15±0.31 b (-0.15) |
98.72±0.20b (1.28) |
97.28±0.15c (2.72) |
| Carrageenan+50mg/kg bw | 100.00±0.00 | 99.15±0.01cd (0.85) |
98.13±0.18c (1.87) |
96.78±0.17 c (3.22) |
96.11±0.30c (3.89) |
|
| Carrageenan+100mg/kg bw | 100.00±0.00 | 98.55±0.16cd (1.45) |
96.14±0.27d (3.86) |
94.20±0.34d (5.80) |
93.87±0.19d (6.13) |
|
| Carrageenan+150mg/kg bw | 100.00±0.00 | 98.59±0.15cd (1.41) |
95.30±0.04de (4.70) |
92.65±0.17e (7.35) |
91.40±0.44e (8.60) |
|
| Carrageenan+200mg/kg bw | 100.00±0.00 | 97.98±0.18d (2.02) |
94.10±0.22ef (5.90) |
91.30±0.18ef (8.70) |
90.06±0.32ef (9.94) |
|
| Carrageenan+250mg/kg bw | 100.00±0.00 | 97.73±0.23 d (2.27) |
93.48±0.20f (6.52) |
90.91±0.34f (9.09) |
89.10±0.19f (10.90) |
|
Descriptive statistics expressed as mean ± SEM for five mice in every group. Values that have different superscript letters are statistically significant along the same column by one-way ANOVA accompanied by Tukey's post hoc test (p≤ 0.005). The values in brackets represent % inflammation inhibition.