Table 4.
Anti-inflammatory effect of dichloromethane leaf extract of S. didymobotrya (Fresenius) on carrageenan-induced inflammation in Swiss albino mice
| Group | Treatment | Percentage change in paw circumference (mm) | ||||
|
| ||||||
| 0h | 1h | 2h | 3h | 4h | ||
|
Normal
control |
DMSO (vehicle) | 100.00±0.00 | 100.00±0.00b (0.00) |
100±0.00b (0.00) |
100.00±0.00b (0.00) |
100.00±0.00b (0.00) |
|
Negative
Control |
Carrageenan + DMSO | 100.00±0.00 | 102.86±0.41a (-2.86) |
106.54±0.42a (-6.54) |
108.40±0.29a (-8.40) |
109.51±0.36a (-9.51) |
|
Positive
Control |
Carrageenan + (Diclofenac 15mg/kgbw) |
100.00±0.00 | 97.27±0.0.21e (2.73) |
94.53±0.41d (5.47) |
92.95±0.21f (7.05) |
91.98±0.16fg (8.02) |
|
DCM:leaf
Extract |
Carrageenan+25 mg/kgbw | 100.00±0.00 | 101.30±0.0.33b (-1.30) |
100.50±0.20b (-0.50) |
98.87±0.20bc (1.13) |
97.41±0.19c (2.59) |
| Carrageenan+50 mg/kgbw | 100.00±0.00 | 100.50±0.20b (-0.50) |
99.50±0.20b (0.50) |
98.01±0.20c (1.99) |
96.84±0.16c (3.16) |
|
| Carrageenan+100 mg/kgbw | 100.00±0.00 | 99.89±0.20cd (1.11) |
97.46±0.15c (2.54) |
96.19±0.29d (3.81) |
95.39±0.16d (4.61) |
|
| Carrageenan+150 mg/kgbw | 100.00±0.00 | 98.60±0.15de (1.40) |
96.29±0.15c (3.71) |
94.89±0.21de (5.11) |
93.66±0.27e (6.34) |
|
| Carrageenan+200 mg/kgbw | 100.00±0.00 | 97.86±0.16de (2.14) |
95.88±0.38cd (4.12) |
94.50±0.13e (5.50) |
92.97±0.24ef (7.03) |
|
| Carrageenan+250mg/kgbw | 100.00±0.00 | 97.59±0.13de (2.41) |
94.57±0.27d (5.43) |
91.69±0.41f (8.31) |
90.95±0.32g (9.05) |
|
Descriptive statistics expressed as mean ± SEM for five mice in every group. Descriptive statistics that have different superscript letters are statistically significant along the same column by one-way analysis of variance accompanied by Tukey's post hoc test (p≤ 0.005). The values in brackets represent % inflammation inhibition.