Table 3.
Association of rs7903146 SNP of TCF7L2 gene according to the model of inheritance in patients and controls
| Genetic Model/s | Genotype | controls n (%) |
cases n (%) |
p value | OR (95% CI) | Adjusted P value |
Adjusted OR (95% CI) |
| Co-dominant |
CC (wild-type) |
24 (41.3) | 18 (15.2) | ||||
| CT (Heterozygous) | 27 (46.5) | 89 (75.4) | <0.0001 | 4.3951 (2.0810 – 9.2822) |
<0.0381 | 1.6244 (1.0269 – 2.5694) |
|
|
TT (homozygous) |
7 (12) | 11 (9.3) | 2.0952 (0.6784 – 6.4707) |
||||
| Dominant model | CC | 24 (41.3) | 18 (15.2) | <0.0002 | - | - | |
| CT-TT | 34 (58.6) | 100 (84.7) | 3.9216 (1.9003 – 8.0929) |
||||
| Recessive | TT | 7 (12) | 11 (9.3) | 0.5728 | 0.7490 (0.2743 – 2.0454) |
- | - |
| CC-CT | 51 87.9) | 107 (90.6) | |||||
| Over dominant | CT | 27 (46.5) | 89 (75.4) | <0.0002 | 3.5236 (1.8126 – 6.8497) |
- | - |
| CC-TT | 31 (53.4) | 29 (24.5) |