Figure 1.

Schematic of nanoparticles’ (NPs) fabrication, characterization, and in vivo and ex vivo experiments. A_1‐3) Leukosomes (Leuko) were fabricated using membrane protein extracted from cultivated leukocytes. A₄) After fabrication, NPs were characterized for their physicochemical and biomimetic properties. B) NPs were tested in vivo using a traumatic brain injury (TBI) mouse model. They demonstrated increased targeting to inflamed organs following TBI, as assessed by two in vivo imaging techniques (i.e., in vivo imaging system [IVIS] and intravital microscopy [IVM]) followed by motor test (rotarod) and several histological and immunohistochemical techniques. This schematic was created using Biorender.com.