Figure 5.

Cerebrovascular targeting of leukosomes in injured mice using intravital microscopy (IVM). TBI mice were systemically injected with NPs immediately after the injury. IVM images capturing the cerebrovascular targeting of A,B) NPs before (baseline) and C,D) 24 h after TBI and NPs administration were acquired. Higher leukosomes (Leuko) adherence to the lesion blood vessel walls was observed compared to the liposomes (Lipo) injected group. E–J) The presence of NPs inside the cerebral vasculature 24 h post‐injection is demonstrated using representative immunofluorescence images of blood vessels (Collagen IV, green) and NPs (red). Scale bar: A–D) 20 µm and E–J) 50 µm.