Figure 7.

Nanoparticles (NPs) administration reduces lesion volume and improves motor recovery after TBI. The effect of NPs on the injured brain lesion was measured using histological techniques. A) Representative images of brain sections stained with cresyl‐violet 24 h after TBI followed by administration of liposomes (Lipo), leukosomes (Leuko), or vehicle (Vh). The dotted line indicates the lesion area composed of the cavity and edematous area. B) Statistically significant reduced lesion volume was found among NPs treated male groups and Leuko treated female groups compared to their Vh treated counterparts. C) Motor recovery was assessed using the rotarod. NPs treatment improved motor function, but this improvement was statistically different in injured mice treated with Lipo compared to those treated with Leuko. Two‐way ANOVA followed by Tukey's multiple comparison test was used to determine statistical probabilities. *p ≤ 0.05, ^** p ≤ 0.01, n = 5 (TBI), n = 3 (Sham).