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(A) Types of warheads found in FDA-approved drugs. In prodrugs, the warhead is masked. (B) Target moieties covalently bound by FDA-approved drugs. DNA includes all nonspecific alkylating agents (the most commonly modified site is N7 in purines). Cofactors include PLP, heme groups, FAD and NADH. Data source: Supplementary Table 1 (n = 88).
Sec: Selenocysteine.
