Figure 5.

Angiopoietin-like protein 4 driven primary tumor proliferation. (a) Photographs of primary tumors. (b) The mean primary tumor area and (c) mean mice body weight measured before necropsy. The mean primary tumor area for MD Anderson–metastatic breast cancer 231 mGFP or MD Anderson–metastatic breast cancer 231 angiopoietin-like protein 4 mGFP is 3.14 mm² and 20.32 mm², respectively. Average combined mGFP tumor area = 1.16 mm², Average combined angiopoietin-like protein 4 mGFP tumor area = 8.84 mm². The mean weight of mice bearing MD Anderson–metastatic breast cancer 231 mGFP or MD Anderson– metastatic breast cancer 231 Angiopoietin-like protein 4 mGFP xenografts is 25 and 24, respectively. The error bars represent the standard deviation. (n = eight mice per group)