Figure 7.

Metastatic Brain Colonization by MD Anderson–metastatic breast cancer 231 Angiopoietin-like protein 4 mGFP cells. (a and b) Brains were resected 4 weeks after intracardiac injection of MD Anderson–metastatic breast cancer 231 mGFP or MD Anderson–metastatic breast cancer 231 angiopoietin-like protein 4 -mGFP cells into the left heart ventricle of nude mice (n = three mice per group). (a) The number of mice-expressing mGFP metastases derived from the MD Anderson–metastatic breast cancer 231 mGFP or MD Anderson–metastatic breast cancer 231 angiopoietin-like protein 4 mGFP cell lines and (b) fluorescence stereomicrographs mouse brains expressing mGFP human triple-negative breast cancer brain metastases. Arrowheads indicate metastatic outgrowth