Table 3.
in silico Lipinski rule of five, lead like rule, CMC like rule, MDDR like rule, and WDI like rule prediction for 6-hydroxy-3,4-dihydronaphthalen-1-on chalcone-like derivatives possessing tyrosinase inhibitory activity.
| Compounds | CMC like rule | Lead like rule | MDDR like rule | Lipinski's rule of five | WDI like rule |
|---|---|---|---|---|---|
| C1 | Qualified | Violated | Mid-structure | Suitable | In 90% cutoff |
| C2 | Qualified | Violated | Mid-structure | Suitable | In 90% cutoff |
| C3 | Qualified | Violated | Mid-structure | Suitable | In 90% cutoff |
| C4 | Qualified | Suitable1 | Mid-structure | Suitable | In 90% cutoff |
| C6 | Qualified | Violated | Mid-structure | Suitable | In 90% cutoff |
| C7 | Qualified | Violated | Mid-structure | Suitable | In 90% cutoff |