Table 4.

in silico ADME profiling of 6-hydroxy-3,4-dihydronaphthalen-1-on chalcone-like derivatives possessing tyrosinase inhibitory activity.

Compounds	Absorption			Distribution
	Human intestinal absorption (%) 0 - 20 (poor) 20 - 70 (moderate) 70 - 100 (good)	in vitro caco-2 cell permeability (nm/s) <4 (low) 4–70 (moderate) >70 (high)	in vitro MDCK cell permeability (nm/s) < 25 (low) 25–500 (moderate) >500 (high)	in vitro skin permeability (log Kp, cm/h-)	in vitro plasmaprotein binding (%) > 90 (strong) < 90 (weak)	in vivo blood-brain barrier penetration (C.brain/C.blood) < 0.1 (low) 0.1 - 2 (moderate) > 2 (high)
C1	95.60	28.01	20.28	-2.64	94.93	1.08
C2	95.97	34.48	4.55	-2.99	91.47	0.13
C3	95.60	5.80	0.39	-2.64	94.89	0.95
C4	93.45	21.56	19.10	-2.73	97.04	1.55
C6	95.62	32.09	14.78	-3.09	89.08	0.20
C7	96.46	25.47	39.32	-2.52	100.00	4.46
Kojic acid	79.39	3.79	9.77	-4.78	20.53	0.26