Fig. 5.

Light photomicrograph of hematoxylin and eosin-stained sections of the mice striatum that were exposed to different doses of METH and TQ (original magnification 400×). Mice received intraperitoneal METH (10 mg/kg) four times a day in 2-h intervals and TQ at 5, 10, and 20 mg/kg, 30 min before each METH injection. Arrows indicate Rosenthal fibers. (A) Control group, no gliosis; (B) TQ at 20 mg/kg, no gliosis; (C) METH, high grad gliosis; (D) METH + TQ 5 mg/kg, high grad gliosis; (E) METH + TQ 10 mg/kg, moderate gliosis; (F) METH + TQ 20 mg/kg, mild gliosis. METH, Methamphetamine; TQ, thymoquinone