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Reagents and conditions for the synthesis of compounds 15a-l: (a) EtOAC, Et2NH, 0 °C, 3 h; (b) pH adjust to 1 (HCl 1N); (c) CH2Cl2, reflux, 3 h, yield = 58%; (d) NH4Cl, NaN3, DMF, 80 °C, 8 h, yield = 80%; (e) EtOH, reflux, 3 h; (f) Et3N, tetrahydrofuran, -10 °C, 1 h; (g) H2O, tetrahydrofuran, RT, 3 h; (h) trifluoroacetic acid, tetrahydrofuran, H2O, RT, overnight; (i) EDC/HOBT, DMF, Et3N, RT, 16 h.
