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Evaluation of synergic effects of racemic racecadotril and compounds 15j and 15l with morphine and antagonist effect of naloxone on racecadotril and compounds 15j and 15l in the hot plate test. The values represent mean ± SEM, n = 6. *P < 0.05 and **P < 0.01 indicate significant differences from saline as the vehicle. M, Morphine; rac, racecadotril.
