Table 2.

Antinociceptive activity of the synthesized compounds 15a-l in comparison to morphine and racecadotril using the tail-flick test.

Compound	Latency time (s)						ED50 (mg/kg)
	20 mg/kg		40 mg/kg		80 mg/kg
	0 min	60 min	0 min	60 min	0 min	60 min
15a	3.37 ± 0.88	5.7 ± 0.69	3.49 ± 0.22	6.11 ± 0.44	3.48 ± 0.18	6.11 ± 0.40	595.8
15b	3.27 ± 0.18	5.26 ± 0.58	3.38 ± 0.59	7.85 ± 0.48	3.36 ± 0.80	7.85 ± 0.76	110.1
15c	3.3 ± 0.33	5.33 ± 0.56	3.47 ± 0.76	5.86 ± 0.55	3.42 ± 0.11	5.86 ± 0.38	516.7
15d	3.33 ± 0.17	4.73 ± 0.38	3.4 ± 0.71	5.94 ± 0.91	3.46 ± 0.56	5.94 ± 0.29	248.3
15e	3.39 ± 0.86	6.15 ± 0.77	3.42 ± 0.43	8.54 ± 0.54	3.24 ± 0.70	8.54 ± 0.82	91.32
15f	3.49 ± 0.37	6.4 ± 0.57	3.36 ± 0.77	7.88 ± 0.74	3.27 ± 0.53	7.88 ± 0.53	127.7
15g	3.24 ± 0.55	7.62 ± 0.46	3.42 ± 0.61	8.99 ± 0.48	3.34 ± 0.43	8.99 ± 0.56	79.86
15h	3.25 ± 0.89	7.69 ± 0.37	3.27 ± 0.51	9.64 ± 0.31	3.33 ± 0.11	9.64 ± 0.12	51.76
15i	3.43 ± 0.44	5.53 ± 0.49	3.49 ± 0.28	6.65 ± 0.07	3.5 ± 0.14	6.65 ± 0.48	234.4
15j	3.44 ± 0.54	9.61 ± 0.75	3.51 ± 0.74	12.9 ± 0.17	3.31 ± 0.11	14.6 ± 0.91	6.147
15k	3.27 ± 0.66	7.99 ± 0.59	3.44 ± 0.66	10.18 ± 0.13	3.29 ± 0.27	10.18 ± 0.95	38
15l	3.41 ± 0.67	9.12 ± 0.74	3.52 ± 0.12	12.65 ± 0.81	3.51 ± 0.31	14.11 ± 0.12	10.82
Saline	3.41 ± 0.46	3.45 ± 0.49	3.28 ± 0.10	3.62 ± 0.39	3.39 ± 0.17	3.4 ± 0.11	896.2
Morphine1	3.38 ± 0.26	10.6 ± 0.281	-	-	-	-	-
Racecadotril	3.25 ± 0.16	5.66 ± 0.12	3.24 ± 0.52	9.88 ± 0.64	3.39 ± 0.47	10.37 ± 0.78	53.69

¹Morphine was given at the dose of 5 mg/kg.