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. 2021 Jun 30;16(4):341–357. doi: 10.4103/1735-5362.319573

Table 3.

The effect of the synthesized compounds 15a-l, morphine, and racecadotril on the number of licking after the injection of formalin into paw in mice.

Compound Concentration (mg/kg) First phase Licking (min) Second phase Licking (min)
20 7.27 ± 0.47 8.85 ± 1.00
15a 40 7.12 ± 0.72 7.83 ± 0.36
80 5.15 ± 0.29 4.08 ± 0.56
20 7.27 ± 0.38 8.97 ± 0.88
15b 40 6.54 ± 0.34 8.52 ± 0.85
80 5.15 ± 0.92 7.84 ± 1.03
20 4.15 ± 0.54 7.03 ± 0.82
15c 40 7.01 ± 0.52 6.15 ± 1.00
80 6.09 ± 0.63 4.58 ± 0.98
20 7.27 ± 0.14 7.11 ± 0.95
15d 40 6.84 ± 0.57 6.98 ± 1.04
80 6.29 ± 0.76 6.49 ± 0.44
20 6.39 ± 0.84 8.44 ± 1.00
15e 40 7.13 ± 0.82 7.89 ± 0.82
80 6.72 ± 0.30 7.03 ± 0.24
20 6.88 ± 0.21 7.39 ± 0.22
15f 40 7.49 ± 0.57 6.98 ± 0.72
80 7.33 ± 0.76 6.11 ± 0.31
20 5.28 ± 0.59 6.35 ± 1.05
15g 40 6.23 ± 0.34 5.15 ± 0.35
80 5.68 ± 0.11 4.78 ± 0.63
20 6.88 ± 0.46 7.19 ± 0.21
15h 40 6.14 ± 0.44 6.72 ± 0.89
80 5.28 ± 0.59 6.35 ± 1.05
20 5.92 ± 0.31 8.68 ± 0.09
15i 40 7.27 ± 0.25 8.17 ± 0.61
80 6.87 ± 0.29 7.74 ± 0.11
20 4.21 ± 0.25 8.02 ± 0.26
15j 40 3.71 ± 0.40 6.19 ± 1.00
80 3.11 ± 0.15 3.77 ± 0.26
20 6.84 ± 0.63 7.11 ± 0.27
15k 40 6.29 ± 0.31 6.98 ± 0.19
80 5.92 ± 0.22 6.49 ± 0.60
20 5.09 ± 0.32 6.78 ± 0.16
15l 40 3.68 ± 0.50 5.89 ± 0.22
80 2.24 ± 0.13 3.48 ± 0.11
Saline 90 7.32 ± 0.13 9.16 ± 0.89
Morphine 5 3.34 ± 0.08 2.86 ± 0.27
20 6.09 ± 0.87 7.57 ± 0.34
Racecadotril 40 6.78 ± 0.65 7.15 ± 0.31
80 6.34 ± 0.66 5.71 ± 0.36