Table 3.

in vitro permeation parameters for lidocaine HCl from jojoba oil microemulsions through excised rat skin into phosphate-buffered saline (pH 7.4) at 37 ^°C. Data represent mean ± RSD, n = 3.

Microemulsion formulation	Flux (μg/cm2.h)	Lag time (h)	Permeation coefficient ([cm/h] × 10-2)	Cumulative drug permeated at 24 h (%)
M1	146.79 ± 0.05	2.92 ± 0.06	0.04	76.7
M2	220.61 ± 1.97	2.99 ± 0.01	0.06	90.3
M3	243.75 ± 0.17	9.09 ± 0.01	0.06	35.4
M4	461.98 ± 0.05	2.87 ± 1.72	0.12	92.4
M5	916.90 ± 0.03	2.07 ± 0.02	0.23	96.5