| Production |
NOS byproduct |
NOS |
| RSNO decomposition NH2OH oxidation |
| NO reduction |
| Direct effect – molecular targets |
Thiols |
Free radicals |
| Metal complexes (specially Fe3+) |
Metal complexes (specially Fe2+) |
| Indirect effects |
Formation of oxidative species from reaction with O2
|
RNOS formation: NO2, N2O3 and ONOO−
|
| Physiological activity |
Vasodilation |
|
|
Neuromodulation and neurotoxic in CNS |
|
|
Favours myocardial contraction |
Macrophage and immune response activation |
| Protection against ischemia/reperfusion injuries |
Mitochondrial hemeprotein regulation |
