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Gasp latency (A) and frequency (B) in TPH2+/+ given vehicle (DMSO; open circles; n = 8) or MDL-11,939 (MDL; closed circles; n = 10). Significant differences between groups indicated by * (P < 0.05) and ** (P < 0.01), assessed using a two-tailed t tests. C: survival curves of TPH2+/+ given vehicle (open circles) and TPH2+/+ given MDL (closed circles) across the five episodes of severe hypoxia. f, frequency; TPH2, tryptophan hydroxylase 2; TPH2+/+, wild-type mice; Veh, vehicle.
