Table 2.

Summary of defensive responses to looming/sweeping stimuli in mice with RGC subpopulation defects

Genotype	Looming		Sweeping		RGCs Affected
	Flight	Freeze	Freeze	Flight
Brn3bWT/WT	0.59	0.26	0.71	0.06	None
Brn3bKO/WT	0.45	0.25	0.87	↑0.28	None described
Brn3bKO/KO	↓↓0.05	0.37	↓0.39	0.08	75% loss
Rax:Cre; Brn3bCKOAP/WT	0.53	0.21	0.60	0.43	None described
Rax:Cre; Brn3bCKOAP/CKOAP	↓↓0.04	0.35	0.54	↓0.15	75% loss
Rax:Cre; Brn3bCKOAP/KO	↓↓0.03	0.34	↓0.37	↓0.20	75% loss
Rax:Cre; Brn3aCKOAP/WT	0.61	0.15	0.80	0.27	None described
Rax:Cre; Brn3aCKOAP/KO	↓0.32	0.27	0.70	↓0.03	20% ≅ “betta RGCs”
Brn3bcDTA/WT	0.53	0.22	0.64	0.22	None described
Opn4Cre/WT	0.50	0.11	0.69	0.36	None described
Opn4Cre/WT; Brn3bcDTA/WT	↓0.25	0.32	0.80	↓0.16	ipRGCs except M1-SCN
Brn3cCre/WT	0.25	0.11	0.61	0.32	None described
Brn3cCre/WT; Brn3bcDTA/WT	↓0.10	0.28	↑0.88	↓0.13	OFF widefield

For each genotype, the flight and freeze response frequencies during stimulus are reported (columns 2–5). The last column reports the affected retinal ganglion cell (RGC) populations, based on previous publications. The arrows indicate significant changes, relative to control strains. Two arrows signify larger differentials. SCN, suprachiasmatic nucleus; ip, intrinsically photosensitive. Spacing highlights the groups of experimental and control animals (i.e., Brn3b^KO/KO vs. Brn3b^WT/WT, Rax:Cre; Brn3b^CKOAP/CKOAP or Rax:Cre; Brn3b^CKOAP/KO vs. Rax:Cre; Brn3b^CKOAP/WT, Rax:Cre; Brn3a^CKOAP/KO vs. Rax:Cre; Brn3a^CKOAP/WT, Opn4^Cre/WT; Brn3b^cDTA/WT vs. Opn4^Cre/WT or Brn3b^cDTA/WT, Brn3c^Cre/WT; Brn3b^cDTA/WT vs. Brn3c^Cre/WT).