TABLE 1.
Demographic and clinicopathologic characteristics stratified by nodal disease status and SLNB negative statusa
| Overall (N = 154) | Nodal disease | P value | SLNB negative status | P value | |||
|---|---|---|---|---|---|---|---|
| Negative (n = 141) | Positive (n = 13) | True (n = 141) | False (n = 7) | ||||
| Age, mean (SD) | 61.3 (14.9) | 61.0 (14.9) | 64.9 (14.5) | .365 | 61.0 (14.9) | 71.0 (11.0) | .054 |
| Sex, N (%) | .701 | .607 | |||||
| Male | 127 (82.5) | 117 (83.0) | 10 (76.9) | 117 (83.0) | 5 (71.4) | ||
| Female | 27 (17.5) | 24 (17.0) | 3 (23.1) | 24 (17.0) | 2 (28.6) | ||
| Breslow thickness, mean (SD) | 1.9 (1.6) | 1.8 (1.6) | 2.4 (1.8) | .268 | 1.8 (1.5) | 2.2 (1.5) | .592 |
| T stage, N (%) | .170 | .519 | |||||
| T1 | 43 (30.3) | 42 (32.3) | 1 (8.3) | 42 (32.3) | 1 (16.7) | ||
| T2 | 57 (40.1) | 52 (40.0) | 5 (41.7) | 52 (40.0) | 2 (33.3) | ||
| T3 | 27 (19.0) | 23 (17.7) | 4 (33.3) | 23 (17.7) | 2 (33.3) | ||
| T4 | 15 (10.6) | 13 (10.0) | 2 (16.7) | 13 (10.0) | 1 (16.7) | ||
| Clark's level, N (%) | .148 | .397 | |||||
| ≤3 | 40 (38.8) | 39 (41.5) | 1 (11.1) | 39 (41.5) | 1 (16.7) | ||
| >3 | 63 (61.2) | 55 (58.5) | 8 (88.9) | 55 (58.5) | 5 (83.3) | ||
| Ulceration Bx, N (%) | .722 | 1 | |||||
| Absent | 81 (63.8) | 76 (64.4) | 5 (55.6) | 76 (64.4) | 3 (60.0) | ||
| Present | 46 (36.2) | 42 (35.6) | 4 (44.4) | 42 (35.6) | 2 (40.0) | ||
| Mitotic rate, N (%) | .481 | 1 | |||||
| <1 | 49 (39.2) | 47 (40.5) | 2 (22.2) | 47 (40.5) | 2 (50.0) | ||
| ≥1 | 76 (60.8) | 69 (59.5) | 7 (77.8) | 69 (59.5) | 2 (50.0) | ||
| LVI, N (%) | 1 | 1 | |||||
| Absent | 112 (92.6) | 104 (92.0) | 8 (100.0) | 104 (92.0) | 4 (100.0) | ||
| Present | 9 (7.4) | 9 (8.0) | 0 (0.0) | 9 (8.0) | 0 (0.0) | ||
| PNI, N (%) | 1 | 1 | |||||
| Absent | 113 (93.4) | 105 (92.9) | 8 (100.0) | 105 (92.9) | 4 (100.0) | ||
| Present | 8 (6.6) | 8 (7.1) | 0 (0.0) | 8 (7.1) | 0 (0.0) | ||
| Subsite, N (%) | .023 | .194 | |||||
| Non‐scalp | 107 (69.5) | 102 (72.3) | 5 (38.5) | 102 (72.3) | 3 (42.9) | ||
| Scalp | 47 (30.5) | 39 (27.7) | 8 (61.5) | 39 (27.7) | 4 (57.1) | ||
| Number of SLNs, N (%) | .571 | 1 | |||||
| 1 | 84 (54.5) | 78 (55.3) | 6 (46.2) | 78 (55.3) | 4 (57.1) | ||
| >1 | 70 (45.5) | 63 (44.7) | 7 (53.8) | 63 (44.7) | 3 (42.9) | ||
| SLN status, N (%) | ‐ | ‐ | |||||
| True positive | 6 (3.9) | 0 (0.0) | 6 (46.2) | 0 (0.0) | 0 (0.0) | ||
| True negative | 141 (91.6) | 141 (100.0) | 0 (0.0) | 141 (100.0) | 0 (0.0) | ||
| False negative | 7 (4.5) | 0 (0.0) | 7 (53.8) | 0 (0.0) | 7 (100.0) | ||
Abbreviations: LVI, lymphovascular invasion; PNI, perineural invasion; SLN, sentinel lymph node; SLNB, sentinel lymph node biopsy.
a
Boldface indicates P < .05.