TABLE 2.

Summary of genomic alterations

Author	Type of alteration	# of patients	Genes
Cha et al, 201617	Mutations	1	TP53 (missense), CDKN2C (loss of function)
Classe et al, 201812	Insertion/deletion	27	CDKN2A, CTR9
	Stop/gain		RB1, TP53
	Non‐synonymous SNV		ARID1A, BRCA2, BRIP1, CHD7, DNMT3A, DNMT3B, EXO1, FZD9, GLI2, GLI3, HERC2, IDH2, KDM2B, KIT, KMT2A, KMT2C, KMT2D, LEF1, MSH3, NAA10, NUMA1, RBBP4, SMARCA4, SMARCC1, SMC2, TOPBP1, TP53, XRCC1, YWHAE
Gallia et al, 201818	Deletions	14	Dystrophin, LAMA2
Gay et al, 201710	Short variants, truncations, and rearrangements	41	ARID1A, ARID2, ATM, AXL‐ARHGEF fusion, BCOR, CDKN1B, CDKN2C, CTCF, CTNNB1, DAXX, IDH2, KDM5C, LRP1B deletion, NF1, NRAS, PBRM1, PIK3CA, PIK3R2, PTCH1, PTEN, SMARCA4, TET2, TNFAIP3, TP53, TSC1,
	Focal copy number alterations		Amplification: BCL2L1, BCL2L2, CDK6, HGF, FGF14, GNAS, IRS2, KIT, MDM4, MYC, PIK3C2B, RICTOR Loss: ARID2, CDKN2A, CDKN2B, CDKN2C, FAF1, MLH1, NF1, PTPRD, TP53, RB1,
	Non focal amplifications		ARFRP1, AURKA, FGF10, FGFR4, FLT4, GATA6, LYN, PDGFRB, RICTOR, SRC, TOP1, ZNF217,
Kim et al, 201750	Recurrent and/or pathogenic somatic mutations	6	ANKHD1, ARHGEF9, ATM, CNOT10, CSDM1, DCTN1, ITSN1, LMTK2, MACF1 (recurrently mutated), MAP2K1, MMRN2, MYOCD, RCE1, RORB, SDCCAG8, ZNF471
	Inter‐chromosomal in‐frame fusion gene		DHRS2‐GSTM2 (recurrent in two samples)
Topcagic et al, 201820	Mutations	15	APC, c‐KIT, CTNNB1, FH, SMAD4, TP53,
	Variants of unknown significance		CDH1, cMet, EGFR, PDGFRA,
Lazo de la Vega et al, 201721	Mutations	18	CTNNB1, KMT2A, KMT2C, PTEN, TP53
	Copy number alterations		Loss: CDKN2A, CDKN2B Gain: FGFR3, CCND1
	Frameshift insertion		DCC, RNF213
Wang et al, 201651	Missense mutations	1	EGFR, FGFR2, KDR, RET
Weiss et al, 201248	Insertion/deletions /gain/loss	1	Deletions: ARID4B, CCDC120, CYP4A22 Insertions: KCNA10, OBSCN
	Gene mutations		KDR, MAP4K2, MYC, NLRC4, SIN3B, TAOK2, TP53,