Table 3.
Demographic data and mRNA levels from TNF-α secreting cells.
| MDD (n = 10) | Controls (n = 10) | Fold change | p | |
|---|---|---|---|---|
| Age (years) | 44.5 ± 10.8 | 42.3 ± 9.4 | 0.634 | |
| Onset (years) | 37.2 ± 13.0 | |||
| Duration (years) | 7.4 ± 8.2 | |||
| BMI (kg/m2) | 23.6 ± 2.9 | 24.2 ± 3.6 | 0.678 | |
| Ham-D score | 14.2 ± 14.9 | |||
| SOCS1 (-ΔCt) | 6.9 ± 0.6 | 6.0 ± 1.0 | 0.6 ± 0.2 | 0.063 |
| TOLLIP (-ΔCt) | 10.9 ± 0.7 | 11.4 ± 0.5 | 1.5 ± 0.6 | 0.089 |
| SIGIRR (-ΔCt) | 7.6 ± 0.3 | 5.6 ± 2.1 | 0.2 ± 0.5 | 0.023* |
| TNFAIP3 (-ΔCt) | 0.50 ± 0.4 | 0.7 ± 0.7 | 2.4 ± 0.7 | 3.2 × 10−4* |
| MyD88s (-ΔCt) | 6.7 ± 0.7 | 7.0 ± 0.7 | 21.8 ± 1.5 | 0.631 |
*
p < 0.05.
BMI, body mass index; Ham-D, 17-item Halmiton Depression Rating Scale; MDD, major depressive disorder; MyD88s, the short form of MyD88; SIGIRR, single immunoglobulin interleukin-1-related receptor; SOCS1, suppressor of cytokine signaling 1; TLR, Toll-like receptors; TNFAIP3, TNF-α-induced protein 3; TOLLIP, Toll-interacting protein.