FIGURE 6.

Associations between pre‐ to post‐HDBR+CO₂ FC values and SANS biomarkers. Scatterplots show relationships between the number of risk alleles, Vitamin B6 and B12 concentration, and homocysteine with participants' change in FC from pre‐ to post‐HDBR+CO₂ (i.e., BDC‐7 to HDT29). Triangle markers indicate participants who developed signs of SANS during the HDBR+CO₂ intervention (SANS). Square markers indicated participants who did not develop signs of SANS (NoSANS). Dashed lines indicate the linear trendline across all 11 participants. (a) In the upper panel, the y axes of plots indicate FC changes between the ROI in right posterior parietal cortex and target clusters in bilateral insular cortices. (b) In the lower panel, the y axes of plots indicate FC changes between the ROI in left posterior cingulate cortex and target clusters in right primary visual cortex (V1). FC, functional connectivity; L, left; ROI, region of interest; SANS, spaceflight associated neuro‐ocular syndrome