Table 4.
Odds of being cognitively resilient to intermediate or high AD pathology versus not adjusted for demographic characteristics and non-AD neuropathology findings
| Demographic-adjusted* OR (95% CI) | p-value | Demographic and non-AD neuropathology adjusted** OR (95% CI) | p-value | |
|---|---|---|---|---|
| College degree | ||||
| No | 1.0 | 1.0 | ||
| Yes | 2.19 (1.23, 3.88) | 0.01 | 2.01 (1.01, 3.99) | 0.047 |
| CERAD | ||||
| Intermediate | 1.0 | 1.0 | ||
| Frequent | 0.53 (0.30, 0.95) | 0.03 | 0.82 (0.40, 1.70) | 0.60 |
| Braak | ||||
| III | 1.0 | 1.0 | ||
| IV | 0.37 (0.12, 0.96) | 0.04 | 0.50 (0.17, 1.49) | 0.21 |
| V | 0.25 (0.11, 0.57) | 0.001 | 0.38 (0.15, 0.99) | 0.048 |
| VI | 0.08 (0.03, 0.21) | <0.001 | 0.12 (0.04, 0.32) | <0.001 |
| Cortical or deep microinfarcts | ||||
| 0–1 | 1.0 | 1.0 | ||
| 2+ | 0.42 (0.21, 0.85) | 0.02 | 0.34 (0.15, 0.78) | 0.01 |
| Hippocampal sclerosis | ||||
| No | 1.0 | 1.0 | ||
| Yes | 0.23 (0.08, 0.69) | 0.01 | 0.28 (0.09, 0.89) | 0.03 |
| Lewy bodies in isocortex | ||||
| No | 1.0 | 1.0 | ||
| Yes | 0.36 (0.10, 1.31) | 0.12 | 0.35 (0.09, 1.44) | 0.15 |
| Brain weight (per gm) | 1.003 (1.001–1.006) | 0.004 | 1.004 (1.001, 1.007) | 0.004 |
*
adjusted for age at baseline, age at death, and college degree.
**
adjusted for age at baseline, age at death, college degree, CERAD, Braak, microinfarcts, hippocampal sclerosis, Lewy body disease, and brain weight. Model includes 258 observations with non-missing data.