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. 2021 Jul 30;17(7):e1009715. doi: 10.1371/journal.pgen.1009715

Fig 1. LSD1/2 homology between C. elegans and humans.

Fig 1

(A) Schematic of human LSD1 and LSD2 proteins shown with the corresponding C. elegans homologs underneath. amx-1(ok659) carries a large deletion encompassing the SWIRM domain and most of the amine oxidase domain. ZF = zinc finger domain. (B) Representative amino acid sequence alignment of worm, human, mouse and fly LSD2 homologs. Conservation of the SWIRM and amine oxidase domains are shown. For a full amino acid sequence alignment, see S1 Fig. (*) denotes a single, fully conserved residue; (:) represents conservation between groups of highly similar properties and (.) indicates conservation between groups of weakly similar properties. (C) Semi-quantitative RT-PCR analysis of whole worm lysates from amx-1(ok659) mutants reveals a 90% reduction in mRNA expression compared to wild type, suggesting that ok659 is a null mutant. gpd-1 is an internal mRNA expression control.