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. 2021 Aug 11;16(8):e0255801. doi: 10.1371/journal.pone.0255801

Fig 1. Results from Mendelian randomization (MR) of outcome variables in UK Biobank and external datasets.

Fig 1

MR results for blood pressure and anthropometric measures (a), lipid and glycemic biomarkers (b), as well as disease outcomes and death (c). Mendelian randomization analysis outcomes for two-stage least squares (2SLS), inverse variance weighted (IVW), and multivariate Mendelian randomization (MVMR) methods in the UK Biobank (UKB) or external datasets. Beta or odds ratio (OR) [95% confidence interval (CI)] for one additional drink/day as instrumented by rs1229984 or by the indicated number of SNPs present from the 25 SNP instrumental variable (IV) set. Significant results shown in black with circles; non-significant results shown in gray with squares. * = the strongest SNP, rs1229984, was not available in the listed dataset. Sample sizes: FinnMetSeq 19,291; GIANT (2018) 449,889; GIANT (2012) 133,154; BFP GWAS 100,716; EXTEND 7,159; GIANT (2015) 232,101; GLGC (2017) 300,000; GLGC (2013) 188,577; MAGIC 123,665. Case numbers: CARDIOGRAMplusC4D 60,801; MEGASTROKE 67,162 (all stroke) and 60,341 (ischemic stroke); HERMES 47,309; AF HRC 65,446; DIAMANTE 48,286; DIAGRAM 26,676.