Table 4B.
Relationship between metabolites of the Kyn pathway and cytokines, hsCRP, and BDNF in the healthy control group.
| IL-6 | TNF-α | hsCRP | BDNF | |
|---|---|---|---|---|
| Trp | −0.12 | 0.25 | 0.28 | 0.056 |
| (p = 0.74) | (p = 0.49) | (p = 0.44) | (p = 0.87) | |
| Kyn | 0.64 | 0.61 | 0.33 | −0.25 |
| (p = 0.046) | (p = 0.060) | (p = 0.35) | (p = 0.49) | |
| 3-HK | −0.055 | −0.15 | 0.091 | 0.29 |
| (p = 0.89) | (p = 0.68) | (p = 0.81) | (p = 0.42) | |
| QA | 0.78 | 0.69 | 0.58 | −0.071 |
| (p = 0.010) | (p = 0.040) | (p = 0.10) | (p = 0.86) | |
| 5-HT | −0.33 | 0.45 | 0.46 | 0.073 |
| (p = 0.35) | (p = 0.20) | (p = 0.18) | (p = 0.84) | |
| Kyn/Trp | 0.55 | 0.46 | 0.22 | −0.18 |
| (p = 0.10) | (p = 0.18) | (p = 0.53) | (p = 0.62) | |
| 5-HT/Kyn | −0.35 | 0.37 | 0.50 | −0.054 |
| (p = 0.33) | (p = 0.30) | (p = 0.15) | (p = 0.88) | |
| 3-HK/Kyn | −0.055 | −0.15 | 0.091 | 0.29 |
| (p = 0.89) | (p = 0.68) | (p = 0.81) | (p = 0.42) | |
| QA/Kyn | 0.77 | 0.63 | 0.58 | −0.075 |
| (p = 0.021) | (p = 0.070) | (p = 0.11) | (p = 0.84) |
hsCRP, high-sensitivity C-reactive protein; BDNF, brain-derived neurotrophic factor; IL, interleukin; TNF-α, tumor necrosis factor alpha; Trp, tryptophan; Kyn, kynurenine; 3-HK, 3-hydroxykynurenine; QA, quinolinic acid; 5-HT, 5-hydroxytryptamine; KynA, kynurenic acid.
Statistically significant differences at P <0.05 is in bold. Positive correlations are shown in red, negative correlations are shown in blue, and the strength of the correlation is expressed in terms of concentration.