TABLE 5.

Relationship between metabolites of the Kyn pathway and positive and negative syndrome scale scores.

	PANSS-T	PANSS-P	PANSS-N	PANSS-G
Trp	−0.16	0.0021	0.0019	−0.35
	(p = 0.40)	(p = 0.99)	(p = 0.99)	(p = 0.06)
Kyn	−0.17	−0.054	−0.039	−0.28
	(p = 0.38)	(p = 0.78)	(p = 0.84)	(p = 0.14)
3-HK	−0.08	0.12	−0.044	−0.13
	(p = 0.68)	(p = 0.53)	(p = 0.82)	(p = 0.50)
QA	−0.3	−0.21	−0.15	−0.44
	(p = 0.16)	(p = 0.35)	(p = 0.45)	(p = 0.043)
5-HT	0.19	0.099	0.1	0.18
	(p = 0.33)	(p = 0.60)	(p = 0.58)	(p = 0.33)
Kyn/Trp	−0.025	−0.0078	−0.028	−0.0045
	(p = 0.89)	(p = 0.97)	(p = 0.88)	(p = 0.98)
5HT/Kyn	0.22	0.13	0.067	0.27
	(p = 0.25)	(p = 0.51)	(p = 0.73)	(p = 0.14)
3-HK/Kyn	0.078	0.27	0.014	0.048
	(p = 0.68)	(p = 0.15)	(p = 0.94)	(p = 0.80)
QA/Kyn	−0.5	−0.38	−0.24	−0.64
	(p = 0.017)	(p = 0.076)	(p = 0.28)	(p = 0.0014)
IL-6	−0.33	−0.2	−0.28	−0.29
	(p = 0.080)	(p = 0.30)	(p = 0.14)	(p = 0.13)
TNF-α	−0.24	−0.2	−0.13	−0.21
	(p = 0.21)	(p = 0.30)	(p = 0.49)	(p = 0.26)
hsCRP	−0.26	−0.28	−0.04	−0.29
	(p = 0.18)	(p = 0.15)	(p = 0.84)	(p = 0.13)
BDNF	−0.34	−0.21	−0.38	−0.23
	(p = 0.064)	(p = 0.26)	(p = 0.038)	(p = 0.22)

PANSS, Positive and Negative Syndrome Scale; PANSS-T, PANSS Total; PANSS-P, PANSS Positive; PANSS-N, PANSS Negative; PANSS-G, PANSS General; Trp, tryptophan; Kyn, kynurenine; 3-HK, 3-hydroxykynurenine; QA, quinolinic acid; 5-HT, 5-hydroxytryptamine; KynA, kynurenic acid; hsCRP, high-sensitivity C-reactive protein; BDNF, brain-derived neurotrophic factor; IL, interleukin; TNF-α, tumor necrosis factor alpha. Statistically significant differences at P <0.05 is in bold. Positive correlations are shown in red, negative correlations are shown in blue, and the strength of the correlation is expressed in terms of concentration.