Skip to main content
. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: Nat Cancer. 2020 Sep 7;1(9):909–922. doi: 10.1038/s43018-020-00109-0

Extended Data Fig. 2. AAV mediated deletion of ARID1A and ARID1B in the liver leads to organ failure.

Extended Data Fig. 2

a. Gross inspection of plasma from mice injected with AAV-GFP or AAV-Cre.

b–f. Liver function tests of Arid1af/f; Arid1bf/f mice injected with AAV-GFP or AAV-Cre (n=10 and 10 mice for AST; 9 and 10 for ALT; 9 and 11 for TBIL; 10 and 11 for ALKP; 9 and 11 for Albumin. Data are presented as mean ± SD. Statistical significance was determined by two-tailed unpaired Student’s t-tests with Welch’s correction).

g. Representative genome browser tracks showing ARID1A binding to the promoter or enhancer regions of differentiation and Cytochrome P450 genes in liver.

h. IHC staining of EpCAM and CK-19 on AAV-Cre liver sections.