Table 6.

Univariate and multiple Cox regression analyses of PESI predictors for long-term mortality after acute PE^*

	31–90-day mortality** (N=354)		91-day-1-year mortality** (N=316)		1–5-year mortality** (N=266)
	HR (95% CI)	P ***	HR (95% CI)	P ***	HR (95% CI)	P ***
Univariate regression analysis
Age (1-year increase)	1.03 (1.00–1.05)	0.033	1.02 (1.00–1.04)	0.026	1.04 (1.03–1.06)	<0.001
Male sex	0.49 (0.24–1.03)	0.060	1.22 (0.67–2.22)	0.513	0.90 (0.56–1.44)	0.651
History of cancer	2.57 (1.31–5.04)	0.006	5.54 (2.96–10.37)	<0.001	5.58 (3.49–8.91)	<0.001
History of heart failure	2.29 (1.07–4.90)	0.033	1.40 (0.63–3.16)	0.411	1.25 (0.64–2.44)	0.511
History of chronic lung disease	2.43 (1.22–4.85)	0.012	1.66 (0.85–3.23)	0.137	1.63 (0.96–2.79)	0.073
Pulse rate ≥110 beats per minute	2.00 (0.83–4.83)	0.123	0.70 (0.22–2.26)	0.552	0.66 (0.27–1.65)	0.376
Systolic blood pressure <100 mm Hg	1.20 (0.37–3.94)	0.760	0.28 (0.04–2.00)	0.202	1.30 (0.59–2.83)	0.514
Respiratory rate ≥30 per minute	2.53 (0.77–8.29)	0.125	2.26 (0.70–7.31)	0.173	1.60 (0.50–5.08)	0.427
Altered mental status	1.53 (0.54–4.34)	0.426	1.19 (0.43–3.34)	0.737	1.51 (0.69–3.30)	0.300
Arterial oxygen saturation <90%	1.94 (0.97–3.87)	0.061	0.63 (0.28–1.41)	0.260	1.61 (0.99–2.64)	0.057
Multiple regression analysis
Age (1-year increase)	1.01 (0.99–1.04)	0.336	1.02 (1.00–1.05)	0.071	1.04 (1.02–1.06)	<0.001
Male sex	0.47 (0.22–1.03)	0.059	0.93 (0.50–1.75)	0.821	0.94 (0.57–1.55)	0.806
History of cancer	3.31 (1.64–6.68)	0.001	5.45 (2.86–10.40)	<0.001	5.53 (3.41–8.98)	<0.001
History of heart failure	2.35 (1.04–5.32)	0.041	1.51 (0.63–3.65)	0.355	0.83 (0.40–1.72)	0.621
History of chronic lung disease	2.02 (0.93–4.35)	0.074	1.49 (0.73–3.04)	0.275	1.57 (0.87–2.81)	0.133
Pulse rate ≥110 beats per minute	1.74 (0.57–5.38)	0.334	0.66 (0.15–2.80)	0.571	0.67 (0.21–1.53)	0.262
Systolic blood pressure <100 mm Hg	0.88 (0.21–3.83)	0.873	0.37 (0.04–3.19)	0.367	2.01 (0.82–4.95)	0.128
Respiratory rate ≥30 per minute	1.26 (0.31–5.18)	0.752	1.66 (0.40–6.81)	0.484	1.09 (0.33–3.57)	0.887
Altered mental status	1.84 (0.55–6.11)	0.319	2.17 (0.72–6.51)	0.167	1.76 (0.78–4.02)	0.176
Arterial oxygen saturation <90%	1.33 (0.63–2.81)	0.463	0.53 (0.23–1.27)	0.156	1.05 (0.60–1.84)	0.874

^*The body temperature criterion could not be evaluated for long-term mortality because any mortality was not observed in patients meeting that parameter and surviving after 30 days

^**Five patients without follow-up data after 30 days, four patients without follow-up data after 90 days, and seven patients without follow-up data after one year were only included in mortality analysis of the periods with available follow-up data

^***Bold values indicate statistical significance

N - number of patients with available follow-up information; HR - hazard ratio; CI - confidence interval; PESI - pulmonary embolism severity index