Table 3.

Basic characteristics of inclusion literature.

Reference and year	Country	Study design	Participants	Tumor category	Auricular acupoints	Materials	Interventions	Antiemetics	Outcomes
Lou et al., 2011 [20]	China	Parallel RCT	50	Various cancers	Shenmen, stomach, subcortex, spleen, sympathesis, ear center	Cowherb seeds	AA + antiemetics	Granisetron	(i); (iii); (vi)
Liu et al., 2011 [19]	China	Parallel RCT	127	Lung cancer	Lung, stomach, Shenmen, spleen, diazoma, subcortex, large intestine	Cowherb seeds	AA + antiemetics	Granisetron/ondansetron	(v); (Vi)
Chao et al., 2012 [13]	Taiwan, China	Crossover placebo RCT	10	Na	Shenmen, stomach, cardia, sympathesis, subcortex,	Seeds	AA + antiemetics	Granisetron/ondansetron	(ii); (iv)
Jiang et al., 2012 [21]	China	Parallel RCT	85	Na	Stomach, Shenmen, spleen, sympathesis, large intestine	Cowherb seeds	AA + antiemetics	Granisetron	(iii); (vi)
Hong et al., 2014 [22]	China	Parallel RCT	120	Breast cancer	Stomach, Shenmen, spleen, sympathesis, subcortex	Cowherb seeds	AA	Ondansetron	(i); (iii); (vi)
Li et al., 2014 [24]	China	Parallel RCT	91	Lung cancer	Stomach, Shenmen, sympathesis	Cowherb seeds	AA + antiemetics	Ondansetron + DXM	(v)
Hu et al. 2014 [23]	China	Parallel RCT	70	Various cancers	M: stomach, Shenmen, sympathesis; A: spleen, liver	Cowherb seeds	AA + antiemetics	Tropisetron	(v)
Eghbali et al., 2016 [33]	Iran	Crossover RCT	96	Breast cancer	Point zero, stomach, brainstem, Shenmen, cardia	Seeds	AA + standard medications	Standard medications	(ii); (iv)
Peng et al., 2016 [16]	China	Parallel RCT	52	Cervical/endometrial/ovarian cancer	M: Shenmen, diazoma, stomach, cardia, occiput, subcortex, esophagus; A: sympathesis, spleen, liver	Cowherb seeds	AA + antiemetics	Ondansetron + DXM	(i); (iii); (iv); (vi)
Wei et al., 2016 [25]	China	Parallel RCT	90	Na	M: stomach, Shenmen, spleen; A: liver	Cowherb seeds	AA + antiemetics	Azasetron	(v)
Guo et al., 2017 [26]	China	Parallel RCT	64	Gastric cancer	Shenmen, sympathesis, stomach, large intestine, small intestine, Ashi point	Cowherb seeds	AA + antiemetics	Granisetron	(v)
Liu, 2017 [17]	China	Parallel RCT	70	Cervical/endometrial/ovarian cancer	Stomach, liver, small intestine, Shenmen, endocrine	Cowherb seeds	AA	Ondansetron	(i); (iii); (iv); (vi)
Wang et al., 2017 [27]	China	Parallel RCT	52	Bone cancer	Stomach, subcortex, ear center, Shenmen, spleen, sympathesis	Cowherb seeds	AA + antiemetics	Ondansetron	(ii); (iii); (iv)
Wu et al., 2018 [28]	China	Parallel RCT	86	Lung cancer	M: stomach, cardia, subcortex A: liver, sympathesis	Cowherb seeds	AA + antiemetics	Ondansetron	(Iii)
Yang, 2018 [18]	China	Parallel RCT	67	Breast cancer	M: stomach, Shenmen, subcortex, sympathesis; A: liver, spleen	Cowherb seeds	AA + antiemetics	Ondansetron	(i) (iii) (v)
Chen et al., 2019 [29]	China	Parallel RCT	89	Colorectal cancer	Sympathesis, Shenmen, spleen, stomach	Cowherb seeds	AA + antiemetics	Azasetron + DXM	(v)
Nan et al., 2019 [30]	China	Parallel RCT	60	Bone cancer	Stomach, ear center, sympathesis, spleen, Shenmen, subcortex	Cowherb seeds	AA + antiemetics	Ondansetron	(iii); (v)
Wen et al., 2019 [31]	China	Parallel RCT	100	Various cancers	Shenmen, stomach, spleen	Cowherb seeds	AA + antiemetics	Azasetron	(v)
Wang et al., 2020 [32]	China	Parallel RCT	80	Cervical cancer	Shenmen, sympathesis, stomach, subcortex, spleen	Cowherb seeds	AA + antiemetics	Ondansetron	(v)

RCT: randomized controlled trial; Na: not available; M: main points; A: adjunct points; AA: auricular Acupressure; DXM: dexamethasone. Outcomes: (i) nausea relief efficiency; (ii) nausea frequency; (iii) vomiting relief efficiency; (iv) vomiting frequency; (v) overall efficiency of CINV; and (vi) incidence of adverse reactions.