Skip to main content
. 2021 Aug 4;596(7871):296–300. doi: 10.1038/s41586-021-03789-5

Fig. 3. Prp5 blocks the repositioning of U1 and U2 snRNPs that is required to form the tri-snRNP-binding site.

Fig. 3

Molecular organization of U1 and U2 snRNPs in S. cerevisiae pre-A, A (PDB 6G90) and pre-B complexes (PDB 5ZWM and PDB 5ZWN). Movements of U1 and U2 snRNPs during the pre-A to A transition are indicated by curved arrows. All structures were aligned as in Fig. 2. For simplicity, the U1 snRNA stem-loops in the poorly resolved region of the U1 snRNP are not shown in the pre-A, A and pre-B complexes.