Table 2.
Oculomotor characteristics
| Controls (n = 49) | PSP (n = 100) | p | Median of differencesb | |
|---|---|---|---|---|
| SPEM gain, % | 0.80; 0.74–0.83 (0.33–0.96) | 0.47; 0.42–0.51 (0.04–1.45) | < 0.001a | − 0.30; − 0.23/− 0.36 |
| VGRS latency, ms | 263.43; 246.67–277.57 (207.23–348.65) | 372.46; 332.51–393.96 (213.83–1020.70) | < 0.001a | 100.90; 73.13/134.98 |
| VGRS (horizontal) gain, % | 0.89; 0.87–0.90 (0.77–0.99) | 0.73; 0.69–0.75 (0.13–1.12) | < 0.001a | − 0.17; − 0.13/− 0.21 |
| VGRS (up) gain, % | 0.79; 0.75–0.82 (0.58–1.04) | 0.51; 0.48–0.60 (0.03–1.07) | < 0.001a | − 0.26; − 0.19/− 0.32 |
| VGRS (down) gain, % | 0.91; 0.89–0.96 (0.65–1.15) | 0.61; 0.53–0.68 (0.05–1.05) | < 0.001a | − 0.32; − 0.24/− 0.42 |
| VGRS (horizontal) peak eye velocity, °/s | 433.47; 411.00–447.03 (264.48–517.35) | 304.19; 262.46–326.49 (0.38–747.31) | < 0.001a | − 124.83; − 95.45/− 156.17 |
| VGRS (up) peak eye velocity, °/s | 367.55; 356.96–404.83 (209.27–618.32) | 200.46; 154.08–234.53 (54.07–477.78) | < 0.001a | − 183.24; − 139.69/− 218.78 |
| VGRS (down) peak eye velocity, °/s | 401.71; 354.70–419.43 (224.68–524.88) | 222.79; 170.15–266.22 (13.15–587.42) | < 0.001a | − 148.61; − 100.29/− 191.96 |
| VGRS intrusion rate, °/s | 3.67; 3.13–4.29 (1.14–10.60) | 10.35; 9.02–12.09 (3.08–23.20) | < 0.001a | 6.37; 5.13/7.73 |
Data are presented as median, 95% confidence interval of the median (minimum–maximum value). Significant results are shown in bold
VGRS visually guided reactive saccades, SPEM smooth pursuit eye movement
aDifferences in the variables between groups were investigated by Mann–Whitney-U-test for independent samples
bPresentation of the median of differences and the 95% confidence interval