Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between parity, body mass index (BMI), and family history and levels of the Nottingham prognostic index (NPI) in stratified analyses by hormone receptor-expression status among Chinese breast cancer patients
| Characteristic | NPI score | ||
|---|---|---|---|
| Q2 vs Q1 | Q3 vs Q1 | Q4 vs Q1 | |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| HR + | |||
| Parity | |||
| Nulliparous | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 1 | 1.01 (0.61, 1.70) | 1.04 (0.61, 1.76) | 1.39 (0.78, 2.46) |
| 2 | 0.90 (0.52, 1.54) | 1.24 (0.72, 2.16) | 1.71 (0.94, 3.11) |
| ≥3 | 0.73 (0.41, 1.29) | 1.18 (0.66, 2.11) | 1.74 (0.94, 3.25) |
| ORtrend | 0.89 (0.77, 1.02) | 1.10 (0.96, 1.27) | 1.18 (1.02, 1.36) |
| P trend | 0.09 | 0.18 | 0.02 |
| BMI | |||
| Underweight | 0.75 (0.34, 1.65) | 0.98 (0.47, 2.04) | 0.94 (0.45, 2.00) |
| Normal | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Overweight | 1.40 (1.12, 1.75) | 1.54 (1.22, 1.93) | 1.54 (1.23, 1.94) |
| Obese | 1.88 (1.24, 2.83) | 2.56 (1.72, 3.82) | 2.08 (1.37, 3.15) |
| ORtrend | 1.39 (1.17, 1.64) | 1.59 (1.34, 1.87) | 1.49 (1.26, 1.77) |
| P trend | <0.001 | <0.001 | <0.001 |
| Family history | |||
| Absent | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Present | 0.75 (0.52, 1.08) | 0.58 (0.39, 0.86) | 0.64 (0.43, 0.95) |
| P value | 0.11 | 0.007 | 0.02 |
| HR− | |||
| Parity | |||
| Nulliparous | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 1 | 0.40 (0.12, 1.32) | 1.17 (0.27, 5.10) | 0.92 (0.22, 3.73) |
| 2 | 0.48 (0.14, 1.65) | 1.23 (0.27, 5.59) | 0.90 (0.21, 3.82) |
| ≥3 | 0.60 (0.16, 2.18) | 1.60 (0.33, 7.74) | 1.55 (0.35, 6.92) |
| ORtrend | 1.07 (0.79, 1.43) | 1.10 (0.80, 1.52) | 1.17 (0.85, 1.59) |
| P trend | 0.67 | 0.55 | 0.33 |
| BMI | |||
| Underweight | 1.22 (0.19, 7.68) | 1.08 (0.14, 8.07) | 2.03 (0.32, 12.94) |
| Normal | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Overweight | 1.10 (0.69, 1.75) | 1.05 (0.63, 1.73) | 1.42 (0.87, 2.31) |
| Obese | 1.49 (0.58, 3.83) | 1.48 (0.54, 4.02) | 2.31 (0.90, 5.91) |
| ORtrend | 1.13 (0.79, 1.61) | 1.13 (0.77, 1.66) | 1.46 (1.02, 2.10) |
| P trend | 0.49 | 0.53 | 0.04 |
| Family history | |||
| Absent | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Present | 1.63 (0.73, 3.64) | 0.52 (0.17, 1.59) | 1.10 (0.43, 2.77) |
| P value | 0.97 | 0.25 | 0.84 |
OR and 95% CI were from polytomous logistic regression models (Q1 of NPI was the base (comparison) category) with mutual adjustments for parity, body mass index (BMI), age at menarche, and family history. Models were further adjusted for diagnosis year and breast cancer subtype