Table 2.

Video-oculographic parameters of mutation carriers and healthy controls

	ALS gene carriers	healthy controls	pa	C9orf72 carriers	SOD1 carriers	ANOVA pb
Anti-saccades error ratec/%	21, (13–41), 0–100	15, (6–30),0–63	0.0091	24, (12–49), 4–100#	19, (12–36), 0–87	0.0254
Delayed saccades errror rated/%	12, (5–18), 0–91	4, (2–11), 0–21	0.0013	9, (5–19), 0–91#	14, (6–16), 0–68#	0.0035
Number of voluntary gaze shiftse	55, (42–64), 14–114	56, (50–64), 40–98	0.116	55, (46–61), 21–114	51, (42–68), 14–87	0.2861
Intrusion ratef/°/s	3.7, (2,6–6,3), 1.7–14.9	2.9, (2.2–4.5), 1.0–8.7	0.0039	4.9, (2.8–7.2), 1.7–14.9#	3.1, (2.6–5.6), 2.4–11.7	0.0008
SPEM gain/%	90, (76–95), 15–100	91, (77–97), 22–111	0.8196	93, (71–96), 31–100	90, (81–95), 15–100	0.8316
VGRS (horiz.) gaing/%	89, (84–91), 69–95	89, (86–93), 69–97	0.1871	86, (83–90), 69–95#	91, (89–92), 80–94	0.0652
VGRS (down) gaing/%	93, (89–97), 81–112	91, (86–96), 76–110	0.1999	90, (88–97), 81–104	94, (91–97), 81–112	0.4842
VGRS (up) gaing/%	75, (66–84), 52–92	80, (77–84), 62–96	0.0220	71, (65–83), 52–92#	76, (72–85), 57–92	0.0070
VGRS (horiz.) velocityh/°/s	420, (393–471), 349–574	432, (401–464), 245–536	0.6556	440, (398–474), 354–574	415, (394–455), 379–524	0.8144
VGRS (down) velocityh/°/s	391, (329–444), 254–579	393, (349–437), 227–538	0.4159	363, (310–454), 254–579	391, (332–421), 276–462	0.5936
VGRS (up) velocityh/°/s	434, (376–474), 309–551	432, (405–487), 216–599	0.5730	445, (393–502), 309–550	422, (369–462) 310–529	0.5611
VGRS (horiz.) latencyi/ms	219, (208–236), 178–304	216, (202–236), 183–413	0.7048	216, (203–235), 178–304	225, (207–239), 190–255	0.9268
VGRS (vert.) latencyi/ms	230, (213–252), 189–355	237, (215–253), 193–371	0.8748	231, (211–252), 189–307	226, (220–252), 193–287	0.8816

Data are presented as median (interquartile range), minimum–maximum. Bold values indicate significance at p < 0.05. Post hoc statistical comparisons for C9orf72 carriers vs. healthy controls and SOD1 carriers vs. healthy controls which reached statistical significance are indicated as ^#

^aMann–Whitney U test between healthy controls and ALS gene carriers

^bKruskal–Wallis analysis of variances of ranks (ANOVA) between healthy controls, subjects with C9orf72 mutation and SOD1 mutation

^cErroneous responses (pro-saccades)

^dErroneous responses (saccades before cue)

^eSaccades > 10° counted within 30 s

^fSaccadic intrusions > 2° excluding the primary saccade, computed as the sum of saccades within VGRS acquisition time

^gGain of VGRS aimed at targets of 20° eccentricity obtained by linear fitting saccade amplitudes as a function of target steps

^hPeak eye velocity of VGRS aimed at targets of 20° eccentricity obtained by non-linear interpolation along the main sequence

ⁱLatencies of VGRS with respect to primary saccade onset