Fig. 4.

pGlu79-α-synuclein in human SN. a Typical examples of pGlu79-α-synuclein immunoreactivity in human SN of control subjects as well as PD and DLB patients. In control subjects, neuromelanin-containing SN neurons only sparsely contain pGlu79-α-synuclein (black DAB-Ni labelling). In PD and in DLB, the density of neuromelanin-containing neurons is markedly reduced, consistent with the degeneration of dopaminergic SN neurons in these clinical conditions. In addition, a high proportion of neuromelanin-positive neurons contains pGlu79-α-synuclein in PD and DLB cases. b pGlu79-α-synuclein immunoreactivity is also present in pathological structures, such as Lewy bodies (arrows) and Lewy neurites (asterisk) in PD and DLB cases