Table 2.
Human brain tissue (abbreviations see below)
| Case | PMI | Sex | Age (years) | Brain weight (g) | MMSE | UPDRS | Lewy stage | SN | Braak NF B Score | Amyloid phase A Score | Neuritic plaque C Score | NIA-AA | Clinicopathological diagnosis | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AD | PD | DLB | |||||||||||||
| Controls | |||||||||||||||
| 1 | 2.75 | M | 81 | 1190 | 25 | 6.5 | 0 | None | III (B2) | 5 (A3) | C1 | Int | No | No | No |
| 2 | 2.16 | M | 80 | 1140 | 30 | 3 | 0 | None | I (B1) | 5 (A3) | C0 | Low | No | No | No |
| 3 | 2.25 | F | 82 | 940 | 30 | 4 | 0 | None | II (B2) | 0 (A0) | C0 | Not | No | No | No |
| 4 | 1.5 | M | 91 | 1440 | 27 | 11 | 0 | None | III (B3) | 2 (A1) | C0 | Int | No | No | No |
| 5 | 2.16 | M | 82 | 1160 | 28 | 0 | Mild | II (B1) | 1 (A1) | C1 | Low | No | No | No | |
| 6 | 2.5 | M | 73 | 1240 | 30 | 4 | 0 | Mild | III (B2) | 1 (A1) | C1 | Int | No | No | No |
| 7 | 2.75 | M | 78 | 1200 | 28 | 8.5 | 0 | None | II (B1) | 2 (A1) | C1 | Low | No | No | No |
| 8 | 1.5 | M | 97 | 1260 | 30 | 13 | 0 | None | III (B3) | 2 (A1) | C0 | Int | No | No | No |
| 9 | 2.5 | F | 95 | 1298 | 28 | 8 | 0 | None | III (B3) | (A0) | C0 | Not | No | No | No |
| 10 | 3.0 | M | 79 | 1428 | 29 | 3 | 0 | None | III (B3) | 0 (A0) | C0 | Not | No | No | No |
| Mean | 2.31 | 8/2 | 83.8 | 1230 | 28.5 | 6.8 | |||||||||
| PD | |||||||||||||||
| 1 | 2.75 | F | 82 | 1215 | ND | 60 | III | Severe | IV (B3) | 3 (A2) | C2 | Int | No | Yes | No |
| 2 | 2.16 | F | 73 | 1170 | 19 | 78 | IV | Severe | IV (B2) | 3 (A2) | C1 | Int | No | Yes | No |
| 3 | 1.83 | M | 70 | 1300 | 8 | 30.5@ | IIIc | Severe | III (B2) | 2 (A1) | C0 | Low | No | Yes | No |
| 4 | 2.0 | M | 85 | 1460 | 28 | 12@ | III | Severe | III (B2) | ND | C2 | ND | No | Yes | No |
| 5 | 3.5 | F | 78 | 1120 | 18 | 68@ | IV | Severe | IV (B2) | ND | C1 | ND | No | Yes | No |
| 6 | 2.16 | M | 85 | 1320 | 27 | 6 | IIb | None | III (B2) | 3 (A2) | C2 | Int | No | Yes | No |
| 7 | 2.66 | M | 89 | 1200 | 29 | 0 | IIa | Mild | IV (B2) | 4 (A3) | C2 | Int | No | Yes | No |
| 8 | 2.0 | F | 84 | 1220 | 21 | 39.5@ | IIa | Severe | II (B1) | 2 (A1) | C0 | Low | No | Yes | No |
| 9 | 3.5 | M | 72 | 1360 | 25 | 31.5@ | III | Severe | II (B1) | ND | C0 | ND | No | Yes | No |
| 10 | 4.16 | M | 69 | 1210 | 24 | 21 | III | Severe | III (B2) | ND | C0 | ND | No | Yes | No |
| Mean | 2.67 | 6/4 | 78.7 | 1258 | 22.1 | 34.6 | |||||||||
| DLB | |||||||||||||||
| 1 | 3.33 | M | 78 | 1300 | ND | 65 | IV | Severe | I (B1) | 3 (A2) | C2 | Low | Yes | No | Yes |
| 2 | 2.5 | F | 90 | 960 | 24 | III | Mild | III (B2) | 1 (A1) | C1 | Low | No | No | Yes | |
| 3 | 3.75 | M | 87 | 1160 | 22 | III | Moderate | II (B1) | 0 (A0) | C0 | Not | No | No | Yes | |
| 4 | 2.66 | F | 82 | 1075 | 5 | 72 | IV | Moderate | V (B3) | 2 (A1) | C3 | Int | Yes | No | Yes |
| 5 | 2.3 | M | 86 | 1130 | 10 | 22 | IV | Moderate | V (B3) | ND | C3 | ND | Yes | No | Yes |
| 6 | 3.16 | F | 96 | 1195 | ND | III | None | III (B2) | 0 (A0) | C0 | Not | No | No | Yes | |
| 7 | 3.33 | M | 89 | 1250 | 16 | IV | Moderate | III (B2) | 2 (A1) | C1 | Low | No | No | Yes | |
| 8 | 2.0 | M | 89 | 1310 | ND | Int* | ND | III (B2) | ND | C1 | ND | No | No | Yes | |
| 9 | 2.5 | M | 89 | 1225 | ND | Int* | ND | III (B2) | ND | C1 | ND | No | No | Yes | |
| 10 | 2.0 | M | 81 | 1280 | 26 | Neo* | ND | V (B3) | ND | C2 | ND | No | No | Yes | |
| Mean | 2.75 | 7/3 | 86.7 | 1188 | 17.2 | 53.0 | |||||||||
PMI postmortem interval in hours, M male, F female, MMSE last Mini Mental State Examination score before death, UPDRS Unified Parkinson’s Disease Rating Scale Part 3 (motor), @ on medication, all others are off medication; Lewy Stage is by the Unified System, or McKeith where indicated by *; Int intermediate, Neo McKeith neocortical, Unified Stage I Olfactory bulb only, IIa Brainstem predominant, IIb Limbic predominant, III Brainstem and limbic, IV Neocortical, SN substantia nigra pigmented neuron loss, Braak NF Braak neurofibrillary stage, NIA-AA National Institute on Aging–Alzheimer’s Association AD Neuropatholological Change Level, ND not done, Not NIA Not AD