Fig. 5.

Genetic associations with top 10% most cell-type-specific genes and cell-type-specific differentially expressed genes. Genetic associations using a top 10% most cell-type-specific genes in each disease group and b cell-type-specific differentially expressed genes in disease comparisons with controls. Two methods were used to identify associations: Hi–C-coupled MAGMA (H-MAGMA) and stratified LD score regression (sLDSC). The heatmap is coloured by degree of significance with both or either method, with * and ** indicating nominal significance (unadjusted p value < 0.05) or significance (FDR-corrected p value < 0.05; corrected for number of cell types tested). Results available in Supplementary Table 8. AD Alzheimer’s disease, OPC oligodendrocyte precursor cell